Treatment with SYPRINE®

What Is SYPRINE®?

SYPRINE® (trientine hydrochloride) is a type of medicine called a copper-chelating (pronounced “key-lating”) agent used in patients who cannot take penicillamine.1 This means that the medication binds to copper in body tissues where it has built up and carries it into the bloodstream, which carries the bound copper to the kidneys, which filter it into the urine.2
 
Is SYPRINE®a Treatment Option for Me?
  • Wilson’s disease (WD) may be managed effectively when you take your medications as prescribed and follow your doctor’s advice on diet and other health issues
  • If you feel better once you start taking your medications, that’s great! It means they’re working. It does not mean your disease is cured and you can stop taking the drugs because WD is a chronic condition that must be managed throughout your lifespan3
SYPRINE® may be right for you if you have been diagnosed with WD and cannot take penicillamine to treat it; SYPRINE® is not interchangeable with penicillamine and should be used only by patients who experience intolerable or life-threatening side effects from penicillamine.1 Stay in close contact with your healthcare professional and tell him or her about any allergic reactions you have while taking SYPRINE®, including rashes or symptoms of asthma or bronchitis.1 All patients taking SYPRINE®—especially women—should see their doctors frequently to be tested for anemia due to low iron levels, and women should tell their doctor if they’re pregnant or nursing or planning to become pregnant.1
How Often Will I Take SYPRINE®?
Your doctor will determine the right dosage for you based on how your body responds to SYPRINE® and may advise you to take SYPRINE® 2, 3, or 4 times daily.1 You should always take SYPRINE® on an empty stomach, at least 1 hour before meals or 2 hours after meals and at least 1 hour apart from any other drug, food, or milk. Swallow the capsules whole with water and do not open or chew them. If any medication gets on your skin, wash the area with water right away to avoid getting a rash.1
Do not take mineral supplements if you take SYPRINE® because they can block absorption of SYPRINE® into your bloodstream. If you have anemia due to low iron levels, your doctor may prescribe a short course of iron supplements, but it is very important to take these at least 2 hours apart from your SYPRINE® dose because iron and SYPRINE® can interact with each other.1
It’s important that you follow these dosing guidelines because food, mineral supplements, and other medications can interfere with the way SYPRINE® is absorbed into your body.1
For the first month of treatment, take your temperature every night and report any symptoms, such as fever or skin rash, to your doctor.1
If your doctor prescribes SYPRINE®, just remember that it’s one of the most important tools you have to ensure your long-term health!
INDICATIONS AND USAGE
Syprine® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. Syprine is not recommended to treat cystinuria (a condition where a protein known as cystine is excreted into the urine), rheumatoid arthritis, or a disease affecting the bile ducts in the liver known as biliary cirrhosis.
IMPORTANT SAFETY INFORMATION
  • Do not take Syprine if you are allergic to it or any parts of the formulation.
  • You should remain under regular medical supervision the entire time you are taking Syprine. Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women.
  • Take Syprine on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed. For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.
  • Do not take mineral supplements because they may block the absorption of Syprine.
Please click here to see full Prescribing Information for Syprine Capsules.
You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.
References
  1. Syprine [package insert]. Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2014.
  2. National Institute of Diabetes and Digestive and Kidney Diseases. Wilson Disease. http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/wilson-disease/Pages/facts.aspx#sec10. Accessed May 25, 2016.
  3. Wilson Disease Association. Treatment of Wilson disease. http://www.wilsonsdisease.org/wilson-disease/wilsondisease-treatment.php. Accessed July 1, 2016.

©2016 Valeant Pharmaceuticals North America LLC. All Rights Reserved. SYP.0024.USA.16

 

Indications and Usage

Syprine® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. Syprine is not recommended to treat cystinuria (a condition where a protein known as cystine is excreted into the urine), rheumatoid arthritis, or a disease affecting the bile ducts in the liver known as biliary cirrhosis.

Important Safety Information

  • Do not take Syprine if you are allergic to it or any parts of the formulation.
  • You should remain under regular medical supervision the entire time you are taking Syprine. Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women.
  • Take Syprine on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed. For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.
  • Do not take mineral supplements because they may block the absorption of Syprine.
Please click here to see full Prescribing Information for Syprine Capsules.
 

INDICATIONS AND USAGE

Syprine® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. SYPRINE® is not recommended to treat cystinuria (a condition where a protein known as cystine is excreted into the urine), rheumatoid arthritis, or a disease affecting the bile ducts in the liver known as biliary cirrhosis.

IMPORTANT SAFETY INFORMATION

  • Do not take Syprine if you are allergic to it or any parts of the formulation.
  • You should remain under regular medical supervision the entire time you are taking Syprine. Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women.
  • Take Syprine on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed. For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.
  • Do not take mineral supplements because they may block the absorption of Syprine.
Please click here to see full Prescribing Information for Syprine Capsules.