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Treatment with SYPRINE® (trientine hydrochloride) for Wilson’s disease

Wilson’s disease can be effectively treated with a low copper diet and chelating agents that bind copper to facilitate its excretion from the body. SYPRINE® is a chelating agent indicated for treatment of patients with Wilson’s disease who are intolerant of the first-line treatment, penicillamine.3

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What is
SYPRINE®?

SYPRINE® is an effective therapy for Wilson’s disease.4,5 SYPRINE® is a copper-chelating agent, with a polyamine-like structure chemically distinct from penicillamine. It lacks sulfhydryl groups and copper is chelated by forming a stable complex with the 4 constituent nitrogens in a planar ring.6 SYPRINE® binds to copper in body tissues where it has built up and carries it into the bloodstream and then to the kidneys, which filter it into the urine.7

Remind your patient that Wilson’s disease may be managed effectively with medications and diet. It is crucial that he or she does not stop taking his or her medication if he or she begins to feel better, because Wilson’s disease is a chronic condition that must be managed throughout life6 SYPRINE® may be right for your patient if he or she has been diagnosed with Wilson’s disease; SYPRINE® is not interchangeable with penicillamine and should be used only by patients who experience intolerable or life-threatening side effects from penicillamine.3 Ask your patient about any allergic reactions he or she might have had while taking SYPRINE®, including rashes or symptoms of asthma or bronchitis.3 All patients taking SYPRINE®—but especially women—should be frequently tested for anemia. Remind female patients to tell you if they become pregnant, plan to nurse, or plan to become pregnant.3

SYPRINE® is contraindicated in patients hypersensitive to SYPRINE® or any components of the formulation. Patients should be observed closely for signs of possible hypersensitivity. Patients receiving SYPRINE® should remain under regular medical supervision throughout the period of drug administration. Patients (especially women) should be closely monitored for evidence of iron deficiency anemia.

When determining the correct dosage for your patients, consider how they respond to SYPRINE®.

You may advise them to take SYPRINE® 2, 3 or 4 times daily.3 SYPRINE® should always be taken on an empty stomach, at least 1 hour before meals or 2 hours after meals and at least 1 hour apart from any other drug, food or milk. The capsules should be swallowed whole with water and not opened or chewed. If any medication comes into contact with the skin, the area should be washed with water right away to avoid development of a rash.3

Mineral supplements should not be taken with SYPRINE®, as they can block absorption of SYPRINE® into the bloodstream. A short course of iron supplements may be prescribed to patients with anemia, but these must be taken at least 2 hours apart from SYPRINE®, as iron and SYPRINE® can interfere with each other.3

Remind your patient of the importance of following these dosing guidelines because food, mineral supplements and other medications can interfere with how SYPRINE® is absorbed into the body.3

For the first month of treatment, the patient’s temperature should be measured every night and symptoms such as fever or skin rash should be reported.3

WD Rx Access

Providing support for people living with Wilson's disease.

The WD Rx Access program offers $5 monthly co-pays, medication home delivery and one-on-one nurse coaching for eligible commercially insured patients. By signing up patients will also receive the WD Rx Access newsletter, The Word on Wilson’s, with helpful tips and information.

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Indication

SYPRINE® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. SYPRINE® is not recommended to treat cystinuria (a condition where a protein known as cystine is excreted into the urine), rheumatoid arthritis, or a disease affecting the bile ducts in the liver known as biliary cirrhosis.

Important Safety Information
  • Do not take SYPRINE® if you are allergic to it or any parts of the formulation.
  • You should remain under regular medical supervision the entire time you are taking SYPRINE®. Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women.
  • Take SYPRINE® on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed. For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.
  • Do not take mineral supplements because they may block the absorption of SYPRINE®.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information for SYPRINE® Capsules.

Indication
Indication

SYPRINE® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. SYPRINE® is not recommended to treat cystinuria (a condition where a protein known as cystine is excreted into the urine), rheumatoid arthritis, or a disease affecting the bile ducts in the liver known as biliary cirrhosis.

Important Safety Information
Important Safety Information
  • Do not take SYPRINE® if you are allergic to it or any parts of the formulation.
  • You should remain under regular medical supervision the entire time you are taking SYPRINE®. Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women.
  • Take SYPRINE® on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed. For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.
  • Do not take mineral supplements because they may block the absorption of SYPRINE®.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information for SYPRINE® Capsules.