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INDICATIONS AND USAGE

SYPRINE® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. Unlike penicillamine, SYPRINE is not recommended to treat cystinuria or rheumatoid arthritis because it is not effective in these conditions, or biliary cirrhosis.

IMPORTANT SAFETY INFORMATION
  • Do not take SYPRINE if you are allergic to it.
  • You should remain under regular medical supervision the entire time you are taking SYPRINE.
    • Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women. Your doctor should also check for free copper in your blood.
  • Take SYPRINE on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed.
  • For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
  • Do not take mineral supplements because they may block the absorption of SYPRINE.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have beenreported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.
INDICATIONS INDICATIONS AND USAGE
IMPORTANT SAFETY INFORMATION IMPORTANT SAFETY INFORMATION
INDICATIONS AND USAGE
INDICATIONS AND USAGE

SYPRINE® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. Unlike penicillamine, SYPRINE is not recommended to treat cystinuria or rheumatoid arthritis because it is not effective in these conditions, or biliary cirrhosis.

IMPORTANT SAFETY INFORMATION
IMPORTANT SAFETY INFORMATION
  • Do not take SYPRINE if you are allergic to it.
  • You should remain under regular medical supervision the entire time you are taking SYPRINE.
    • Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women. Your doctor should also check for free copper in your blood.
  • Take SYPRINE on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed.
  • For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
  • Do not take mineral supplements because they may block the absorption of SYPRINE.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have beenreported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.